Low sequence similarity may yield very similar structures.Sequencesimilarity Why Comparing Protein Folded Structures? Given a new structure, the probability is high that it is similar to an existing one.Three possible reasons: - evolution, - physical constraints (e.g., few ways to maximize hydrophobic interactions), - limits in techniques used for structure determination.Is expected to reflect functional similarities (interaction with other molecules).1xis 1nar backbone format Alignment computed by DALI ahelix axes
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